| Summary, etc |
Diabetes mellitus is a prevalent metabolic disorder that leads to other microvascular and macrovascular<br/>complication, affecting both men and women. It has thus been discovered to have an adverse effect on the<br/>fertility of men as a result of diabetic induced oxidative stress (Omolaoye, et al., 2018), which damages<br/>the sperm cell. Carica papaya is usually used in folklore medicine to treat many conditions which include<br/>the use of papaya leaf juice in increasing platelet count, treating asthma and other complications (Ankit<br/>and Devendrasinh, 2017). Diabetic male rats were treated with C. papaya extract for a duration of 14 days,<br/>glucose concentration was determined using the Randox glucose kit; 20µl of samples and standard were<br/>mixed with 200µl of working reagent and incubated at 37oC for 10 minutes, the absorbance was read at<br/>500nm against a blank that consisted only the working reagent. Concentration of plasma glucose was<br/>obtained by the calculation: (Absorbance of Sample/Absorbance of Standard) X Standard Concentration<br/>(103mg/dl). Seminal analysis was ran as recorded by Cheesbrough, 2005., for evaluation of morphology,<br/>motility and sperm count under the microscope. Experiment carried out gave results of a significant<br/>decrease in plasma glucose levels in diabetic rats treated with C. papaya extracts as well as metformin<br/>drug. The seminal analysis parameters that were ran also showed a significant increase in the percentage<br/>of motile sperm cells in rats subjected to 200mg/kg body weight extract treatment in comparison to the<br/>diabetic rats with a percentage mean and standard deviation value of 73.10 ± 5.50. The study has shown<br/>that C. papaya may be able to reduce the effect of diabetic induced oxidative stress on the sperm cells,<br/>and improving the fertility of male rats. However, more research is required to investigate the activity of<br/>antioxidants and superoxide dismutase activity in the effect of C. papaya on male fertility |
