| Summary, etc |
Polycystic ovarian syndrome (PCOS) is one of the common causes of female infertility.<br/>Parquetina nigrescens is a plant used in the treatment of various ailments including menstrual<br/>disorders. This work investigated the regulation of ethanolic extracts of Parquetina nigrescens<br/>leaves on oestrous cyclicity and lipid profile in letrozole-induced PCOS rats. After the<br/>induction of letrozole (1mg/kg/day), normal (n=4), and PCOS (n=15; distributed into 4 groups<br/>of 4 animals/group) rats were treated orally for 14 days with distilled water (1m/kg/day),<br/>clomiphene citrate (2mg/kg/day), metformin (500mg/kg/day), and ethanolic extract of<br/>P.nigrescens (50 and 100mg). Oestrous cyclicity, body weight and fasting blood glucose levels<br/>were measured. They were letrozole-induced PCOS characterised by irregular oestrous<br/>cyclicity, elevated (p>0.05) triglycerides, low density lipoprotein cholesterol (LDL), total<br/>cholesterol, insulin, testosterone, and luteinising hormone concentration (LH). Low (p>0.05)<br/>progesterone, follicle stimulating hormone (FSH), high density lipoprotein cholesterol (HDL)<br/>and fasting blood glucose concentration compared to that of the control group. PCOS rats had<br/>altered oestrous cycle compared to that of the control. These reproductive, biochemical and<br/>structural alterations were alleviated by the administration of ethanolic extract of P. nigrescens<br/>leaves (50mg/kg) restored the oestrous cycle after 14 days of treatment. However, the ethanolic<br/>extracts of P.nigrescens (100mg/kg) significantly increased (p>0.05) FSH, HDL and<br/>progesterone concentrations, but decreased the LH, progesterone, and total cholesterol.<br/>Ethanolic extracts of P.nigrescens leaves alleviated regulated the reproductive, hormonal and<br/>structural alterations of PCOS rats. The ethanolic extract of this P.nigrescens leaves can<br/>therefore be used in the management/treatment of the reproductive and metabolic disorders<br/>related to PCOS. |
