| Summary, etc |
Polycystic Ovary Syndrome (PCOS) is an endocrine disorder known by symptoms such as<br/>hyperandrogenism, amenorrhea, and polycystic ovaries. Being an endocrine disorder, its<br/>associated with metabolic dysfunction of the endocrine gland which results to an imbalance of<br/>the sex hormones which include reduced level of follicle stimulating hormone and progesterone<br/>increased level of luteinizing hormone, Insulin and testosterone which causes cyst to form in the<br/>antral ovarian follicle. Among the various reference drugs used in the treatment of PCOS<br/>combination of metformin with clomiphene citrate used in this study, has shown to exhibit a<br/>good therapeutic effect in the management of PCOS. Ethnomedicine such as Parquetina<br/>nigrescens leaves, Aspargus Racemosus, Tinospora Cordifolia etc. have been reported to contain<br/>phytocompounds which showed therapeutic effect in annulling the comorbidities associated with<br/>PCOS. Therefore, this study was aimed at evaluating the ameliorative effect of ethanoic extracts<br/>of V. amygdalina leaves on reproductive and metabolic dysfunctions associated with letrozoleinduced PCOS in female Wistar rats.<br/>The effects of ethanoic extract of V. amygdalina leaves (EEVAL) on reproductive hormones, at<br/>the doses of 50 and 100 mg/kg body weight on PCOS-induced by letrozole was evaluated in<br/>female Wistar rats as well as their lipid profile. Twenty female Wistar rats (170.81 ±5.00g) were<br/>completely randomized into 5 groups (A - E) of 4 each. The animals in group A received 0.5 ml<br/>of distilled water orally on daily basis for 21 days while the letrozole rats in groups B, C, D and<br/>E also received orally 0.5 ml of distilled water, 7.14mg/kg of metformin and 2mg/kg clomiphene<br/>citrate (reference drugs) and different volume of the extract conforming to 50 and 100 mg/kg<br/>body weight of EEVAL respectively. The administration of EEVAL at 100 mg/kg B.W. to<br/>PCOS significantly (p<0.05) increased serum FSH and progesterone concentration, as well as<br/>HDL-C concentration when compared to the control group. It ameliorated PCOS-induced<br/>elevated serum LH, Insulin and Testosterone concentration and as well as TG, TC and LDL-C in<br/>the female rats. In conclusion, the ethanoic extract of V. amygdalina leaves has ameliorative<br/>effects on letrozole-induced reproductive and metabolic dysfunctions associated with PCOS rats,<br/>therefore it can be explored in the management of PCOS.<br/> |
