| Summary, etc |
ABSTRACT<br/>Polycystic ovarian syndrome (PCOS) is an endocrine disorder that is common to women of <br/>reproductive age. This study aims to evaluate the effects of the oral administration of ALA and <br/>olive oil in letrozole-induced polycystic ovarian syndrome rats. Thirty-five rats were randomly <br/>divided and acclimatized into a group of five consisting of seven animals each. Letrozole (1mg/kg) <br/>was administered orally for 14 days to induce PCOS in groups two to five after the period of <br/>acclimatization. Normal control (group 1) and PCOS control group (group 2) received 0.5ml/day <br/>of saline water, and the three groups of PCOS rats were administrated 7.14 mg/kg of metformin <br/>and 2mg/kg of clomiphene citrate (group 3), 1mg/kg body weight of ALA (group 4), and 0.8ml/kg <br/>of olive oil (group 5) for 14 days. Finally, blood samples were collected and ovaries harvested and <br/>fixed in 10% formalin to determine the biological and stereological parameters. Compared to the <br/>PCOS control, the effect of the co-administrated drugs, ALA, and olive oil significantly improved <br/>the testosterone level (p<0.05). Although ALA and the co-administrated drugs caused a significant <br/>decrease in the LH level, no significant change was observed in terms of LH level in the olive oil <br/>group compared to the PCOS control group (p<0.05). There was a modest significance (p<0.05) <br/>or no change observed in the effect of the co-administrated drugs, ALA, and olive oil on the FSH <br/>level compared to the PCOS control rats. Data of the study showed that the administration of ALA <br/>and olive oil may have beneficial effects on the biochemical factors in PCOS-induced rats. <br/>Keywords: Polycystic ovaries, inflammation, LH, FSH, testosterone, alpha-lipoic acid, Olive oil.<br/> |
