| Summary, etc |
Pre-eclampsia, also known as pregnancy-induced hypertension (PIH), is a type of hypertension that only affects pregnant women and is characterized by elevated blood pressure and proteinuria after the 20th week of pregnancy. It is one of the leading causes <br/>of maternal and foetal morbidity worldwide, accounting for nearly 40% of preterm births with signs of damage to another organ system, most commonly the liver, and kidneys. Cabbage is a cruciferous vegetable that contains various beneficial compounds such as glucosinolates, flavonoids, anthocyanins, carotenoids, tannins, saponins, alkaloids, phenolic compounds, phytosterols, and chlorophylls. It offers several health benefits, including a decreased risk of chronic diseases such as cancer, cardiovascular disease, and diabetes and improved gut health and immune function. Maternal nutritional status during pregnancy has been investigated as a potential treatment target in preventing preeclampsia. This study aims to develop a snack enriched with nutrients from cabbage for pregnant women to satisfy their cravings and serve as a nutraceutical, as well as investigate the effect <br/>of the cabbage-based snack on selected cardiovascular parameters in pre-eclampsia. Feed and cookies were formulated, and the nutritional and sensory properties were assessed. Invivo studies was also carried out with thirty-five female rats, which were completely randomised into 7 groups. The effect of continued feeding with the diet was observed. The data obtained from the results were subjected to statistical analysis using Analysis of ariance (ANOVA). The values obtained ranged from 16.89% to 18.27%,4.03 to 2.40%, 3.03 to 8.60%, 9.00 to 13.33%, 2.50 to 3.33%, 59.83 to 61.89 % for protein, fibre, moisture, fat, ash, and carbohydrate contents respectively. The cabbage diet had the highest ash and fibre content. Inclusion of cabbage increased the fibre content significantly (p<0.05). All the formulated diets had a significant effect on the animals. However, the cabbage-based <br/>diet significantly affected the animal weight, fasting blood glucose, hormones, and cardiovascular parameters. The reference drug had a significant regression in the serum prolactin level compared to the control group. In conclusion, the cabbage diet showcased <br/>a promising ability to alleviate pre-eclampsia-related metabolic dysfunctions in rat models. This dietary strategy can potentially reduce pre-eclampsia risks and improve maternal wellbeing during pregnancy.Keywords: Pre-eclampsia, Cabbage, Cardiovascular, Lipopolysaccharide, Cookies |
