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The paper examines the impact of audit characteristics on performance of deposit money bank in Nigeria. The specific objective is to determine the significance of auditor independence, audit fee, audit tenure, audit firm size in the performance of selected deposit money banks in Nigeria. The firm size was used moderating variable. The study was carried out using ex-post facto design method. The population of the study covers the 22 listed deposit money banks in Nigeria as at 31st December 2020. The sample size was 10 banks which were purposively selected from the 22 banks. Data were collected from the annual audited financial statement of the selected bank. The data were analyzed using SSP 23 version. The descriptive and inferential statistic were used to analyze the result. The ROA in hypothesis (1) implies that there is no significant impact of audit committee independence on firm’s performance in Nigeria. (F=0.233 r= 0.007, t=0.483 P= 0.630). The ROA in hypothesis (2) suggested that the result has insignificant impact on the firms’ performance in Nigeria. (F=1.093, r = -0.001 t=-1.046 p= 0.298). The ROA in hypothesis (3) indicate that firms’ size has insignificant impact on the firms’ performance in Nigeria. (F=1.686, r= -0.001 t=-1.298 p= 0.197). The ROA in hypothesis (4) entail that audit fees has insignificant impact on the firms’ performance in Nigeria. (F=0.613, r= 0.12 t= 0.783 p= 0.436). The ROA in hypothesis (5) implies that audit firm size has insignificant impact on the firms’ performance in Nigeria. (F=8.346, r=0.047 t= -2.889 p= 0.005). The ROE in hypothesis (1) means that audit fee has insignificant impact on the firms’ performance in Nigeria. (F=7.238, r=43.362 t= 2.690 p= 0.014. The ROE in hypothesis (2) implies that audit fees has insignificant impact on the firms’ performance in Nigeria. (F=7.238, r=43.362 t= 2.690 p= 0.014). The ROE in hypothesis (3) means that audit firm size has insignificant impact on the firms’ performance in Nigeria. (F=1.180, r- -0.085 t=1.053 p= 0.305). The ROE in hypothesis (4) means that audit tenure has a positive relationship with return on equity of deposit money banks in Nigeria. (F=18.871, t=4.344 p= 0.00) The ROE in hypothesis (5) implies that audit firm size has insignificant impact on the firms’ performance in Nigeria. (F=6.828 r=0.012 t=2.613, p= 0.17). The NPM in hypothesis (1) entails that audit committee independence has insignificant impact on the firms’ performance in Nigeria. (F=0.002, r= -0.017 t=-0.049 p= 0.961). The NPM in hypothesis (2) shows that there is no significant effect of audit fee on firm performance (. (F=0.135, r =0.145 t= 0.367 P= 0.714). The NPM in hypothesis (3) implies that audit firm size has insignificant impact on the firms’ performance in Nigeria. (F=0.217, r-0.200 t=0.466 P= 0.642). The NPM in hypothesis (4) implies that firm size has insignificant impact on the firms’ performance in Nigeria. (F=2.002 r= 0.040t=1.415 p= 0.160). The NPM in hypothesis (5). implies that audit fee has significant impact on the firms’ performance in Nigeria. (F=0.874 r= 0.024 t=0.935 P= 0.352), The recommendation is that there is the need for the regulatory bodies in line with best practices to look critically into the issue of auditor tenure and auditor independence in other to have greater positive impact on the performance of the firms.