TY  - BOOK
AU  - FALOWO, SIMILOLUWA DANIELA
TI  - NEUROPROTECTIVE EFFECT OF AQUEOUS AND ETHANOL LEAF  EXTRACT OF Alafia barteri IN FORMALDEHYDE INDUCED ARTHRITIC  MICE
PY  - 2023///
CY  - Mountain Top University
PB  - BIOCHEMISTRY
KW  - BIOCHEMISTRY
N2  - Arthritis, a chronic condition characterized by inflammation in the joints, remains a significant challenge in the field of healthcare due to the limitations of current treatment options. It is a systemic disease known to affect other organs such as the brain. In this study, Alafia barteri aqueous and ethanol leaf extracts were administered in different concentrations to arthritic mice and the effects on brain function, and some physical parameters were evaluated. Biochemical markers, such as catalase, superoxide dismutase , glutathione, acetylcholine esterase and monoamine oxidase activities were analyzed to identify oxidative stress and neuroinflammation indicators within brain tissue. The results on the body weight showed no significant differences in groups 
exposed to varying aqueous leaf extract concentrations. Paw diameter reduction was observed in all treated groups compared to the arthritic control group. The aqueous leaf extract at 400mg/kgbwt significantly lowered GSH levels. Similarly, the ethanol leaf 
extract at 200mg/kgbwt had decreased GSH concentrations compared to the arthritic control group. Acetylcholine esterase (ACHE) levels decreased in ethanol leaf extract groups (100, 200, and 400mg/kgbwt), Superoxide dismutase (SOD) showed decrease 
in accompared to NAC in while EL200 and AL 100 increase significantly, similarly Catalase showed significant decrease compared to NAC and the the treated groups (el100,200,400mg/kgbwt) significantly decrease, similarly in the aqueous leaf extract. 
When compared to Non arthritic control, AL100 and 200mg/kgbwt increased significantly while EL at 100 and 200mg/kgbwt indicates a significant decrease in Mao level compared to NAC. In conclusion, the study suggests the neuroprotective effects 
of both aqueous and ethanol leaf extracts of Alafia barteri on the brains of arthritic mice. This insight into addressing brain changes related to arthritis warrants further exploration and understanding of Alafia barteri's role.Keywords: Acetylcholine esterase, Alafia barteri, Arthritis, Biochemical analysis
ER  -